endo-BCN CE-Phosphoramidite
| Artikel-Nr. | Packungseinheit | Preis | Vorlaufzeit | Jetzt kaufen |
|---|---|---|---|---|
| 3005-100mg | 100 mg | – | 10 Tagen. | |
| 3005-250mg | 250 mg |
$800.00
|
10 Tagen. | |
| 3005-1g | 1 g |
$2350.00
|
Auf Lager |
Bicyclononyne (BCN) is a stable and one of the most reactive cyclooctynes for Copper-free click chemistry. Unlike dibenzocyclooctyne (DBCO), BCN is reactive both to azides (strain-promoted azyde-alkyne cycloaddition, SPAAC) and tetrazines (inverse electron demand Diels-Alder reaction, IEDDA). Being an endo-stereoisomer, Bicyclononine in endo-BCN CE-phosphoramidite provides a higher rate of cycloaddition compared to its exo-conformer.
BCN-labeled oligonucleotides may be used for the conjugation to azide- or tetrazine-containing solid surfaces, polymers, and large proteins.
Coupling time is standard, like for amidites of natural nucleosides. Exclude the dimethoxytrityl (DMT) removal step and use the Dmt-ON protocol after amidite coupling and oxidation.
Use standard conditions for deprotection and ammonia solution, or AMA mixture (ammonium hydroxide / 40% methylamine, 1:1).
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| Appearance: | yellowish oil |
| Mass spec M+ increment: | 482.58 |
| Molecular weight: | 481.57 |
| Molecular formula: | C24H40F1N3O5P |
| Quality control: | NMR 1H and 31P, HPLC-MS (95%) |
| Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| Sicherheitsdatenblatt:: | herunterladen |
| Product specifications |
Oligo synthesis details
| Diluent: | Anhydrous Acetonitrile |
| Deprotection conditions: | identical to protected nucleobases |
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