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3-(5-methyl-1H-pyrazol-3-yl)propionic acid-d6 (MPP)

Artikel-Nr. Packungseinheit Preis Vorlaufzeit
4337-500ug 0.50 mg
$259
20 Tagen.
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Succinylacetone (abbreviated as SA) is a product of tyrosine catabolism, and an inhibitor of heme biosynthesis. Succinylacetone testing in dried neonatal blood spots, followed by quantitation of SA in blood or urine in high-risk neonates, has excellent sensitivity and specificity for the diagnosis of tyrosinemia type 1 [1].

Succinylacetone is a reactive diketone which reacts with the amino groups of peptides and proteins present in the blood. Therefore, extraction of the bound SA requires its conversion into a product suitable for its extraction and quantification. This is effected by means of hydrazine treatment which leads to a conversion of succinylacetone to this pyrazole derivative.

This pyrazole derivative is a deuterated derivative is used as an analytical standard in the measurement of succinylacetone (SA) in dried blood spot samples.

[1] Kehar M., Sen Sarma M., Seetharaman J., Jimenez Rivera C., Chakraborty P. Decoding hepatorenal tyrosinemia type 1: Unraveling the impact of early detection, NTBC, and the role of liver transplantation. Can Liver J. 2024. 7(1). P.54-63.

General properties

Appearance: white solid
Molecular weight: 160.21
Molecular formula: C7H4D6N2O2
Solubility: in water
Quality control: NMR 1H and HPLC-MS (95+ %, D: 98+ %)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
Sicherheitsdatenblatt: herunterladen
Product specifications
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