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3-(5-methyl-1H-pyrazol-3-yl)propionic acid-d6 (MPP)

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4337-500ug 0.50 mg $259 12 Tagen.
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Succinylacetone-pyrazole-d6 is a deuterated derivative of succinylacetone-pyrazole (SA-pyrazole-d6) and is used as an analytical standard in the measurement of succinylacetone (SA). Succinylacetone is a reactive diketone and reacts with the amino groups of amino acid residues of peptides and proteins present in the blood.

As a result, in order to extract the immobilized SA, it must be converted into a more highly stable product, which is subsequently subjected to extraction, namely a pyrazole derivative.

SA content in tandem mass spectrometry (MSMS) analysis is defined as the content of the derivative compound, 3-(5-methyl-1H-pyrazol-3-yl)propanoic acid (MPP). SA is quantified by adding a stable isotope-labeled propanoic acid analogue as an internal standard.

Succinylacetone is a product of tyrosine catabolism and an inhibitor of heme biosynthesis. Succinylacetone (SA) testing in dried neonatal blood spots, followed by quantitation of SA in blood or urine in high-risk neonates, has excellent sensitivity and specificity for the diagnosis of tyrosinemia type 1 [1]. Succinylacetone also serves as a tool for studying the defects of heme synthesis on cellular processes.

[1] Kehar M., Sen Sarma M., Seetharaman J., Jimenez Rivera C., Chakraborty P. Decoding hepatorenal tyrosinemia type 1: Unraveling the impact of early detection, NTBC, and the role of liver transplantation. Can Liver J. 2024. 7(1). P.54-63.
Struktur von 3-(5-Methyl-1H-pyrazol-3-yl)propionsäure-d6 (MPP)
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General properties

Appearance: white solid
Molecular weight: 160.21
Molecular formula: C7H4D6N2O2
Solubility: in water
Quality control: NMR 1H and HPLC-MS (95+ %, D: 98+ %)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
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Product specifications
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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